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How To Fix Calculating Total Analytical Error
If you have Calculating Total Analytical Error then we strongly recommend that you download and run this (Calculating Total Analytical Error) repair tool.
Symptoms & Summary
Calculating Total Analytical Error and other critical errors can occur when your Windows operating system becomes corrupted. Opening programs will be slower and response times will lag. When you have multiple applications running, you may experience crashes and freezes. There can be numerous causes of this error including excessive startup entries, registry errors, hardware/RAM decline, fragmented files, unnecessary or redundant program installations and so on.
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File Size 746 KB
Compatible Windows XP, Vista, 7 (32/64 bit), 8 (32/64 bit), 8.1 (32/64 bit) Windows 10 (32/64 bit)
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Health Outreach Global Lab Quality Initiative Lab Tests Online Harmonization Membership Grants Travel Grants International Travelers Assistance Menu Login Membership & Community Laboratory Medicine News Science & Practice Meetings & Events Education & Careers Publications Health & Science Policy Global Health Outreach Store About AACC Join & Renew Annual Meeting Media Member Directory Artery Cart Clinical Laboratory News Subscribe CLN Daily CLN Stat CLN Articles Board of Editors Permissions and Reprints ACCENT CE Credit for CLN Articles Contact Us Advertise Home // ... // Clinical Laboratory News // CLN Articles // Total Analytic Error Total Analytic Error From Concept to Application Author: James O. Westgard, PhD, and Sten A. Westgard, MS // Date: SEP.1.2013 // Source: Clinical Laboratory News Topics: Lab Management, Quality Assurance Today clinical laboratories have come under increased pressure to implement quality systems and new risk management guidelines for quality control in order to ensure timely and accurate delivery of test results. However, one issue that is often overlooked in these efforts i
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have written an article about total analytical error in which I am mentioned. Their article says that total analytical error (TAE) is important and estimated by the equation TAE=average bias + 2xSD. They later go on to say that higher multiples of https://jkrouwer.wordpress.com/2013/09/05/total-analytical-error-vs-total-error/ the SD are useful for Six Sigma methods. So what are the problems? Here’s the first problem. The Westgards say (I have added bolding): “After Westgard, Carey, and Wold proposed these definitions, some analysts argued that there were additional components of error that should be considered, such as interferences that affect individual patient samples, sometimes referred to as random biases. To include such effects, Krouwer recommended a direct estimation of TAE obtained by using total error a comparison with a reference method (2), and the Clinical Laboratory Standards Institute (CLSI) subsequently developed the EP21A guidance document using that approach (3).” The use of the word “argued” implies that perhaps this consideration is wrong. It isn’t. The original analysis comes from: Lawton WH, Sylvester EA, Young-Ferraro BJ. Statistical comparison of multiple analytic procedures: application to clinical chemistry. Technometrics 1979;21:397-409. Now this is a technical article. For those that want a simpler version, total allowable error consider the following picture: These assays have the same TAE according to the Westgards because the average bias is the same. But clearly, the assay of the left has more actual TAE than the one on the right. Patient interferences aren’t the only problem. Any intermittent error will inflate the TAE but depending on the error source may not affect either average bias or precision. Moreover, it’s not just large interferences. Say that every sample has a bias from a mixture of interferences that ranges from -1% to +1% bias. The average bias is zero but the SD of differences between the assay and reference will be inflated and not accounted for by the equation average bias + 2 SD. The second problem is perhaps more important. The Westgards say (I have added bolding): “Given that ATE is intended to be an estimate of the quality of a measurement procedure, its practical value depends on a comparison to the quality required for the intended use of a test result. In other words, the definition refers to the amount of error that is allowable without invalidating the interpretation of a test result.” The problem is that a measurement procedure includes all errors made during the conduct of a test including pre-analytical and post-analytical error (e.g., user error). Thus, the Westgards
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Windows Operating Systems:
Compatible with Windows XP, Vista, Windows 7 (32 and 64 bit), Windows 8 & 8.1 (32 and 64 bit), Windows 10 (32/64 bit).